Curriculum Vitae
PD Dr. med. Jörn Dopheide
Geburtsdatum: 27.10.1973 Nationalität: deutsch | GLN-Nr. 7601003540734 ZSR-Nr. V517132 |
Werdegang
21.12.2001 | Promotion |
24.10.2001 | Ärztliche Prüfung Universität des Saarlandes, Homburg/ Saar |
Praktisches Jahr | |
06/2001 –09/2001 | Innere Medizin IV, Nephrologie, Universität des Saarlandes, Homburg/Saar |
02/2001 –05/2001 | Unterassistent Klinik für Herz-Thorax und Gefäßchirurgie, Inselspital, Universität Bern, Schweiz |
10/2000 – 01/2001 | Klinik für Anästhesie, Université de Rennes, Hôpital-Sud, Rennes, Frankreich |
1998 – 2000 | Doktorarbeit: «Evaluation of the importance of Dendritic cells for uremic immuno-deficiency in patients with End Stage Renal Disease», Innere Medizin IV, Nephrologie, Universität des Saarlandes, Homburg/Saar |
1996 – 1997 | Erasmus-Studienaufenthalt Université Louis-Pasteur Strasbourg, Strasbourg, Frankreich |
1996 – 2000 | Klinische Semester, Universität des Saarlandes, Homburg/Saar |
1994 – 1996 | Vorklinische Semester, Universität des Saarlandes, Homburg/Saar |
1994 – 2001 | Studium der Humanmedizin, Universität des Saarlandes, Homburg/Saar |
Berufliche Laufbahn
Seit 09/2023 | Leitender Arzt Angiologie (80%), Leiter Gefässzentrum, STS Spital AG Thun |
Seit 07/2023 | Senior Consultant Vasa Cura Praxis für Gefässmedizin, Burgdorf (20%) |
07/2022 – 06/2023 | Oberarzt, Leiter Funktionsbereich Angiologie, Universitätsklinik der Friedrich Schiller-Universität Jena |
08/2021 – 07/2022 | Oberarzt Innere Medizin (20%) Angiologie und kardiovaskuläre Prävention, Landeskrankenhaus Bregenz, Vorarlberg, Österreich |
12/2020 – 06/2022 | Stv. Leitender Arzt, Angiologie, Departement Innere Medizin Kantonsspital Graubünden, Chur, Schweiz |
27.11.2020 | Facharzt FMH Angiologie |
30.06.2020 | Habilitation an der Universität Bern mit Erhalt der Venia docendi |
04/2016 –10/2020 | Oberarzt I, Universitätsklinik für Angiologie, Inselspital, Universität Bern, Schweiz |
09/2015 – 03/2016 | Funktionsoberarzt, Kardiologie I, Universitätsmedizin Johannes-Gutenberg-Universität Mainz |
07/2014 –06/2015 | Stipendium der Margarete-Waitz-Stiftung |
15.01.2014 | Facharzt für Angiologie |
09/2012 | Kongresssekretär, 41. Jahrestagung der Deutschen Gesellschaft für Angiologie in Mainz |
08.07.2009 | Facharzt für Innere Medizin |
09/2004 –09/2006 | Forschungsaufenthalt als Post Doc Research Fellow am «Whitaker Cardiovascular Institut» bei John F. Keaney, Boston University, Boston, MA, USA, mit dem Forschungsschwerpunkt «Rolle von PGC-1a beim Schutz von Endothelzellen vor oxidativem Stress» |
03/2003 –03/2016 | Assistenzarzt, 2. Med. Klinik und Poliklinik (Kardiologie, Angiologie und Intensivmedizin), Uniklinik der Johannes-Gutenberg-Universität Mainz |
11/2001 –05/2003 | Arzt im Praktikum, 2. Med. Klinik und Poliklinik (Kardiologie, Angiologie und Intensivmedizin), Uniklinik der Johannes-Gutenberg-Universität Mainz |
Forschungs-Schwerpunkte
Einfluss mononukleärer Zellen auf den Verlauf der peripheren arteriellen Verschlusskrankheit
Sekundäre Prävention kardiovaskulärer Erkrankungen mit:
- Schwerpunkt auf Lipide und lipidsenkende Therapie und deren Einfluss auf kardiovaskuläres Outcome bei pAVK Patienten (Kooperation mit Univ. Prof. Dr. med. Dr. h.c. Heinz Drexel, Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT))
- Auswirkungen eines strukturierten Gehtrainings auf den Verlauf der peripheren arteriellen Verschlusskrankheit
Interventions-Studien zu femoro-poplitealen und cruralen Interventionen (Kooperation mit PD Dr. med. Aljoscha Rastan (Kantonsspital Aarau)
Preise, Mitgliedschaften und Sprachen
Preise
Angiologischer Preis (UCB - Pharma Preis) der Deutschen
Gesellschaft für Angiologie (DGA) am 17.09.2013
Schweizer Preis für Angiologie am 01.12.2021
Mitgliedschaften
Deutsche Gesellschaft für Angiologie (seit 2009)
European Society of Cardiology:
- Working Group: Aorta & Peripheral Vascular Diseases
- Working Group: Cardiovascular Pharmacotherapy
FMH Swiss Medical Association
Ärztegesellschaft des Kanton Bern
Ärztlicher Bezirksverein (ABV) Thun
Sprachen
Deutsch (Muttersprache)
Englisch (fliessend)
Französisch (verhandlungssicher)
Publikationen
1. Originalarbeiten (Impact-Faktor Journal Index Universität Bern)
Schlitt A, Heine GH, Blankenberg S, Espinola-Klein C, Dopheide JF, Bickel C, Lackner KJ, Iz M, Meyer J, Darius H, Rupprecht HJ, CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Haemost. 2004 Aug; 92(2):419-24. (IF: 5.249)
Dopheide JF, Sester U, Schlitt A, Horstick G, Rupprecht HJ, Münzel T, Blankenberg S, Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro. Coron Artery Dis. 2007 Nov;18(7):523-31.(IF: 1.439)
Schulz E*, Dopheide J*, Schuhmacher S, Thomas SR, Chen K, Daiber A, Wenzel P, Münzel T, Keaney JF Jr. Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation. 2008 Sep 23; 118(13):1347-57. doi: 10.1161/CIRCULATIONAHA.108.784298. * equally contributing (IF: 26.690)
Dopheide JF, Obst V, Doppler C, Radmacher MC, Scheer M, Radsak MP, Gori T, Warnholtz A, Fottner C, Daiber A, Münzel T, Espinola-Klein C. Phenotypic characterisation of pro-inflammatory monocytes and dendritic cells in peripheral arterial disease. Thromb Haemost. 2012 Dec;108(6):1198-207. doi: 10.1160/TH12-05-0327. Epub 2012 Oct 23. (IF: 5.249)
Dopheide JF, Doppler C, Scheer M, Obst V, Radmacher MC, Radsak MP, Gori T, Warnholtz A, Fottner C, Münzel T, Daiber A, Espinola-Klein C., Critical limb ischaemia is characterised by an increased production of whole blood reactive oxygen species and expression of TREM-1 on neutrophils. Atherosclerosis. 2013 Aug;229(2):396-403.Doi10.1016/j.atherosclerosis.2013.05.029. Epub 2013 Jun 18. (IF: 5.162)
Dopheide JF, Knopf P, Zeller GC, Vosseler M, Abegunewardene N, Münzel T, Espinola-Klein C. Low IL-10/TNFα ratio in patients with coronary artery disease and reduced left ventricular ejection fraction with a poor prognosis after 10 years. Inflammation. 2015 Apr;38(2):911-22. doi: 10.1007/s10753-014-0053-5 (IF: 4.092)
Dopheide JF, Scheer M, Doppler C, Obst V, Stein P, Vosseler M, Abegunewardene N, Gori T, Münzel T, Daiber A, Radsak MP, Espinola-Klein C, Change of walking distance in intermittent claudication: impact on inflammation, oxidative stress and mononuclear cells: a pilot study. Clin Res Cardiol. 2015 Sep;104(9):751-63. doi: 10.1007/s00392-015-0840-5. Epub 2015 Mar 15. (IF: 5.460)
Dopheide JF, Zeller GC, Kuhlmann M, Girndt M, Sester M, Sester U. Differentiation of Monocyte Derived Dendritic Cells in End Stage Renal Disease is Skewed Towards Accelerated Maturation. Adv Clin Exp Med. 2015 Mar-Apr;24(2):257-66. doi: 10.17219/acem/40463. (IF: 1.727)
Dopheide JF, Geissler P, Rubrech J, Trumpp A, Zeller GC, Bock K, Dorweiler B, Dünschede F, Münzel T, Radsak MP, Espinola-Klein C. Inflammation is associated with a reduced number of pro-angiogenic Tie-2 monocytes and endothelial progenitor cells in patients with critical limb ischemia.Angiogenesis. 2016 Jan;19(1):67-78. doi: 10.1007/s10456-015-9489-y.PMID: 26462497 (IF: 9.596)
Dopheide JF, Geissler P, Rubrech J, Trumpp A, Zeller GC, Daiber A, Munzel T, Radsak MP, Espinola-Klein C. (2016) Influence of exercise training on proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease. Clinical Research in Cardiology. Clin Res Cardiol. 2016 Aug;105(8):666-76. doi: 10.1007/s00392-016-0966-0. (IF: 5.460)
Dünschede F, Aftahy K, Youssef M, Dopheide J, Binder H, Dorweiler B, Vahl CF. Propensity Score and Long-Term Survival Results after Open versus Endovascular Treatment of Abdominal Aortic Aneurysm. Zentralbl Chir. 2016 Oct;141(5):518-525 (IF: 0.942)
Dopheide JF, Geissler P, Rubrech J, Trumpp A, Zeller GC, Bock K, Dunschede F, Trinh TT, Dorweiler B, Munzel T, Radsak MP, Espinola-Klein C (2016) Leukocyte Platelet Aggregates– a phenotypic characterization of different stages of peripheral arterial disease. Platelets. 2016 Nov;27(7):658-667. doi:10.3109/09537104.2016.1153619. (IF: 3.862)
Schmidt CS, Aranda Lopez P, Dopheide JF, Schmidt F, Theobald M, Schild H, Lauinger-Lörsch E, Nolte F, Radsak MP. Phenotypic and functional characterization of neutrophils and monocytes from patients with myelodysplastic syndrome by flow cytometry. Cell Immunol. 2016 Oct; 308:19-26. doi: 10.1016/j.cellimm.2016.07.005 (IF: 4.868)
Dünschede F, Paul N, Meyer A, Youssef M, Espinola-Klein C, Dopheide J, Fottner C, Vahl CF, Dorweiler B. Autologous Bypass to Pedal Side Branches to Avoid a Major Amputation. Zentralbl Chir. 2017 Oct;142(5):464-469. doi: 10.1055/s-0041-111181. (IF: 0.942)
Dopheide JF, Rubrech J, Trumpp A, Geissler P, Zeller GC, Schnorbus B, Schmidt F, Gori T, Münzel T, Espinola-Klein C. Supervised exercise training in peripheral arterial disease increases vascular shear stress and profunda femoral artery diameter. Eur J Prev Cardiol. 2017 Jan; 24(2):178-191. doi: 10.1177/2047487316665231. (IF: 7.804)
Dopheide JF, Sebastian T, Engelberger RP, Haine A, Kucher N. Early clinical outcomes of a novel rheolytic directional thrombectomy technique for patients with iliofemoral deep vein thrombosis. Vasa. 2018 Jan;47(1):56-62. doi: 10.1024/0301-1526/a000666. (IF: 1.961)
Sebastian T, Dopheide JF, Engelberger RP, Spirk D, Kucher N. Outcomes of endovascular reconstruction of the inferior vena cava with self-expanding nitinol stents. J Vasc Surg Venous Lymphat Disord. March 2018; doi: 10.1016/j.jvsv.2017.11.012. (IF: 2.859)
Dopheide JF, Papac L, Schindewolf M, Baumgartner I, Drexel H. Poor attainment of lipid targets in patients with symptomatic peripheral artery disease. J Clin Lipidol, May – Jun;12(3):711-717. doi: 10.1016/j.jacl.2018.02.013. (IF: 4.766)
Blum MR, Gencer B, Adam L, Feller M, Collet T, Costa BR, Moutzouri E, Dopheide JF, Depairon M, Sykiotis GP, Kearney P, Gussekloo J, Westendorp R, Stott DJ, Bauer DC, Rodondi N. Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly with Subclinical Hypothyroidism: A Randomized Trial. The Journal of Clinical Endocrinology & Metabolism. 2018:jc.2018-00279-jc.02018-00279. (IF: 5.958)
Sebastian T, Spirk D, Engelberger RP, Dopheide JF, Baumann FA, Barco S, Spescha R, Leeger C, Kucher N. Incidence of Stent Thrombosis after Endovascular Treatment of Iliofemoral or CavalVeins in Patients with the Postthrombotic Syndrome. Thromb Haemost. 2019 Dec;119(12):2064-2073. doi: 10.1055/s-0039-1697955. (IF: 5.249)
Haine A, Schmid MJ, Schindewolf M, Lenz A, Bernhard SM, Drexel H, Baumgartner I, Dopheide JF. Comparison Between Interwoven Nitinol and Drug Eluting Stents for Endovascular Treatment of Femoropopliteal Artery Disease. Eur J Vasc Endovasc Surg. 2019 Dec;58(6):865-873. doi: 10.1016/j.ejvs.2019.09.002. Epub 2019 Oct 25. (IF: 7.069)
Dopheide JF, Veit J, Ramadani H, Adam L, Papac L, Vonbank A, Kaspar M, Rastan A, Baumgartner I, Drexel H. Adherence to statin therapy favours survival of patients with symptomatic peripheral artery disease. Eur Heart J Cardiovasc Pharmacother. 2019 Dec 10:pvz081. doi: 10.1093/ehjcvp/pvz081. (IF: 6.697)
Dopheide JF, Ramadani H, Adam L, Gahl B, Papac L, Veit J, Kaspar M, Schindewolf M, Baumgartner I, Drexel H.Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score. Angiology. 2020 Aug;71(7):658-665. doi: 10.1177/0003319720920155. Epub 2020 Apr 28.PMID: 32342699. (IF: 3.619)
Dopheide JF, Adam L, Wiedmer S, Kaspar M, Silbernagel G, Baumgartner I, Drexel H. Improved lipid target level attainment in patients with peripheral artery disease. Curr Vasc Pharmacol. 2021 Jan 11. doi: 10.2174/1570161119666210111123621. (IF: 2.719)
Drexel H, Mader A, Saely CH, Tautermann G, Dopheide JF, Vonbank A. Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance. Sci Rep. 2021 Jul 15;11(1):14503. doi: 10.1038/s41598-021-93879-1. (IF: 4.379)
Leiherer A, Mündlein A, Brandtner EM, Säly CH, Ramadani H, Vonbank A, Mader A, Dopheide JF, Jylhä A, Lääperi M, Laaksonen R, März W, Fraunberger P, Kleber M, Drexel H. Lipid profiles of patients with manifest coronary versus peripheral atherosclerosis - is there a difference? J Intern Med. 2021 Aug 1. doi: 10.1111/joim.13368. (IF: 8.989)
Koppe-Schmeißer F, Schwaderlapp M, Schmeißer J, Dopheide JF, Münzel T, Daiber A, Espinola-Klein C. Influence of Peripheral Transluminal Angioplasty Alongside Exercise Training on Oxidative Stress and Inflammation in Patients with Peripheral Arterial Disease. J Clin Med. 2021 Dec 13;10(24):5851. doi: 10.3390/jcm10245851. (IF: 4.964)
Sudano I, Mach F, Moccetti T, Burkard T, Fahe C, Delabays A, Rickli H, Keller PF, Dopheide J, Bodenmann S, Fiolka T, Ehret G, Spirk D. Optimized Treatment of Refractory Hypercholesterolemia in Patients With Atherosclerotic Cardiovascular Disease or Heterozygous Familial Hypercholesterolemia With Alirocumab (OPTIMIZE). Front Cardiovasc Med. 2022 Jul 15;9:953040. doi: 10.3389/fcvm.2022.953040. eCollection 2022.PMID: 35911507 (IF: 3.6)
Kaspar M, Bott A, Rastan A, Dopheide JF, Drexel H, Schindewolf M. Preoperative Factors Associated with Target Lesion Revascularization following Endovascular Therapy of the Superficial Femoral Artery. J Clin Med. 2022 Aug 8;11(15):4606. doi: 10.3390/jcm11154606.PMID: 35956221 (IF: 3.9)
Dopheide JF, Gillmann P, Spirk D, Khorrami Borozadi M, Adam L, Drexel H. False versus True Statin Intolerance in Patients with Peripheral Artery Disease. J Clin Med. 2022 Nov 8;11(22):6619.doi: 10.3390/jcm11226619.PMID: 36431097 (IF: 3.9)
Adam L, Strickler E, Borozadi MK, Bein S, Bano A, Muka T, Drexel H, Dopheide JF. Prognostic Role of Polyvascular Involvement in Patients with Symptomatic Peripheral Artery Disease. J Clin Med. 2023 May 11;12(10):3410. doi: 10.3390/jcm12103410.PMID: 37240515 (IF: 3.9)
2. Übersichtsarbeiten
Steven S, Daiber A, Dopheide JF, Münzel T, Espinola-Klein C. Peripheral artery disease, redox signaling, oxidative stress - Basic and clinical aspects. Redox Biol. 2017 Aug;12:787-797. doi: 10.1016/j.redox.2017.04.017.
Vonbank A, Drexel H, Agewall S, Lewis BS, Dopheide JF, Kjeldsen K, Ceconi C, Savarese G, Rosano G, Wassmann S, Niessner A, Schmidt TA, Saely CH, Baumgartner I, Tamargo J. Reasons for disparity in statin adherence rates between clinical trials and real-world observations: a review. Eur Heart J Cardiovasc Pharmacother. 2018 Oct 1;4(4):230-236. doi: 10.1093/ehjcvp/pvy028.
Drexel H, Rosano GMC, Lewis BS, Huber K, Vonbank A, Dopheide JF, Mader A, Niessner A, Savarese G, Wassmann S, Agewall S. The age of randomized clinical trials: three important aspects of randomized clinical trials in cardiovascular pharmacotherapy with examples from lipid and diabetes trials. Eur Heart J Cardiovasc Pharmacother. 2020 Apr 1;6(2):97-103. doi: 10.1093/ehjcvp/pvz029.
Drexel H, Lewis BS, Rosano GMC, Saely CH, Tautermann G, Huber K, Dopheide JF, Kaski JC, Mader A, Niessner A, Savarese G, Schmidt TA, Semb A, Tamargo J, Wassmann S, Kjeldsen KP, Agewall S, Pocock SJ. The age of randomized clinical trials: three important aspects of randomized clinical trials in cardiovascular pharmacotherapy with examples from lipid, diabetes, and antithrombotic trials. Eur Heart J Cardiovasc Pharmacother. 2020 Nov 2:pvaa126. doi: 10.1093/ehjcvp/pvaa126.
Dopheide, J.F., Drexel, Heinz (03/ 2020). Lipidsenkende Therapie zur Sekundärprävention der peripheren arteriellen Verschlusskrankheit: Einfluss der neuen Leitlinien der Europäischen Gesellschaft für Kardiologie/Europäischen Atherosklerose Gesellschaft (ESC/EAS). Gefässchirurgie, 25(3), pp. 160-165. Springer-Medizin-Verlag 10.1007/s00772-020-00629-0
Rastan A, Dopheide JF, Baumgartner I. Claudicatio intermittens bei peripherer arterieller Verschlusskrankheit: Teil 1. Swiss Med. Forum. 2020;20(4950):724-728. DOI: https://doi.org/10.4414/smf.2020.08598
Rastan A, Dopheide JF, Baumgartner I. Claudicatio intermittens bei peripherer arterieller Verschlusskrankheit: Teil 2. Swiss Med Forum. 2020;20(5152):778-781. DOI: https://doi.org/10.4414/smf.2020.08606
Drexel H, Pocock SJ, Lewis BS, Saely CH, Kaski JC, Rosano GMC, Tautermann G, Huber K, Dopheide JF, Mader A, Niessner A, Savarese G, Schmidt TA, Semb AG, Tamargo J, Wassmann S, Clodi M, Kjeldsen KP, Agewall S.Subgroup analyses in randomized clinical trials: Value and limitations Review #3 on important aspects of randomized clinical trials in cardiovascular pharmacotherapy. Eur Heart J Cardiovasc Pharmacother. 2021 Jun 28:pvab048. doi: 10.1093/ehjcvp/pvab048.
3. Editorials
- Espinola-Klein C, Dopheide JF, Gori T, Ankle-brachial index in chronic kidney disease. Vasa. 2012 May;41(3):159-60.
- Espinola-Klein C, Dopheide JF, Gori T, Change of ankle-brachial index and progression of atherosclerosis. Vasa. 2013 Mar;42(2):86-7. doi: 10.1024/0301-1526/a000250.